Anti-Non-selenium Glutathione Peroxidase
Recommended Replacement for: AB3700| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | WB, IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P30041 # Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
SIZE: 224 amino acids; 25035 Da
SUBUNIT: Homotetramer. May interact with HTR2A (By similarity). Interacts with STH.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Lysosome (By simila ... see more »
SIZE: 224 amino acids; 25035 Da
SUBUNIT: Homotetramer. May interact with HTR2A (By similarity). Interacts with STH.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Lysosome (By simila ... see more »
Entrez Gene Number:
Entrez Gene Summary
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Description:
Anti-Non-selenium Glutathione Peroxidase
Trade Name:
Chemicon (Millipore)
Key Applications:
- Western Blotting
- Immunohistochemistry
Application Notes:
Western blotting: 1:1000-1:4000
Immunohistochemistry on frozen or wax embedded tissue: 1:200-1:2,000. Antigen retrieval is not necessary but optimal working dilutions will need to be determined.
STAINING PATTERN: Stains cytoplasm of epithelial cells in the rat and mouse lung and gut and rat and human brain astrocytes. Stains human astrocytes in Parkinson's and Alzheimer's disease and the central core of some Lewy bodies in dementia with Lewy bodies and Parkinson's disease.
Optimal working dilutions must be determined by the end user.
Immunohistochemistry on frozen or wax embedded tissue: 1:200-1:2,000. Antigen retrieval is not necessary but optimal working dilutions will need to be determined.
STAINING PATTERN: Stains cytoplasm of epithelial cells in the rat and mouse lung and gut and rat and human brain astrocytes. Stains human astrocytes in Parkinson's and Alzheimer's disease and the central core of some Lewy bodies in dementia with Lewy bodies and Parkinson's disease.
Optimal working dilutions must be determined by the end user.
Species Reactivity:
- Human
- Rat
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Alternate Names:
NSGP, Clara Cell Protein 26, 1-Cys Peroxiredoxin
Antibody Sub-Category:
Oxidative Stress
Specificity:
Nonselenium glutathione peroxidase (NSGP, Clara cell protein 26 kDa, 1-Cys peroxiredoxin).
Antibody Category:
Neuroscience
Gene Symbol:
- PRDX6
- p29
- 1-Cys
- Peroxiredoxin-6
- MGC46173
- KIAA0106
- PRX
- NSGPx
- aiPLA2
- AOP2
- EC 1.11.1.15
- EC 3.1.1.-
- EC 1.11.1.7
Format:
Serum
Presentation:
Rabbit serum. Liquid.
Immunogen:
Recombinant rat nonselenium glutathione peroxidase.
Antibody Type:
Polyclonal Antibody
Replaces:
AB3700
Storage Conditions:
Maintain material at -20°C under sterile conditions for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Host:
Rabbit